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There is no known interaction between Hydrochlorothiazide and Lexapro in our records. However, an interaction may still exist. Always consult your doctor before taking these medications together. Do not stop taking the medications without a physician's advice. Lexapro Precautions and Warnings - Depression Home Page A few other Lexapro precautions and warnings include the safety of taking Lexapro if you have a seizure disorder or are over 65 years old, and the risk of allergic reactions or withdrawal symptoms in some people taking the drug.

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